尽管临床上应用多种药物治疗,但多发性骨髓瘤仍然是一种不可治愈的疾病,因此需要研究开发针对瘤细胞和骨髓微环境的新的治疗药物,硼替佐米已被证实具有明显的抗骨髓瘤活性,我们在应用硼替佐米治疗过程中有3例患者发生了急性肾功能衰竭,考虑肾功能的恶化与肿瘤细胞溶解有关,现报告如下,并结合文献进行讨论。 Despite the clinical use of multiple drug treatments, multiple myeloma remains an incurable disease and there is a need to study and develop new therapies that target the tumor cells and the bone marrow microenvironment. Bortezomib has been shown to have significant resistance Myeloma activity, we use bortezomib in the course of treatment of acute renal failure occurred in 3 patients, consider the deterioration of renal function and tumor cell lysis, are reported below, and combined with the literature to discuss.