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目的探讨血清尿酸与高血压患者左心室肥厚(LVH)的关系,以及这种关系在男女之间是否存在差异。方法选择福建省级机关医院原发性高血压患者2140例,根据血清尿酸水平四分位数分组,比较4组的左心室质量指数(LVMI)和左心室肥厚(LVH)发生率;按男、女分层,比较男、女尿酸四分位组间LVMI和LVH发生率的差异;采用多因素Logistic回归分析男、女患者尿酸与LVH发生的关系。结果随着尿酸四分位水平递增,女性患者LVMI和LVH发生率逐渐增加[分别为(114.41±34.51),(121.34±36.98),(126.86±42.52),(141.74±46.36)g/m2;35.0%,47.0%,52.1%,61.7%;均P<0.05],而男性患者4组间LVMI差异有统计学意义[分别为(144.12±76.44),(132.58±40.39),(134.24±41.00),(141.84±55.02)g/m2;P<0.05],LVH发生率差异无统计学意义(57.1%,50.2%,54.3%,52.7%;P>0.05)。和女性相比,男性尿酸、LVMI升高,LVH发生率增加(均P<0.05)。Logistic回归分析显示,尿酸是女性患者中LVH发生的独立危险因素[OR(95%CI)=1.30(1.13~1.56),P<0.01],男性患者中尿酸与LVH的相关性无统计学意义(P>0.05)。结论尽管女性高血压患者尿酸及LVH程度较男性低,但女性患者尿酸与LVH相关,而男性患者这种相关性无统计学意义。
Objective To investigate the relationship between serum uric acid and left ventricular hypertrophy (LVH) in hypertensive patients and whether there is any difference in the relationship between men and women. Methods A total of 2140 patients with essential hypertension in Fujian Provincial Hospital were selected and divided into four groups based on serum uric acid levels. The incidence of left ventricular mass index (LVMI) and left ventricular hypertrophy (LVH) Female stratification was used to compare the incidence of LVMI and LVH among male and female utero-uric acid quartiles. Multivariate Logistic regression was used to analyze the relationship between uric acid and LVH in male and female patients. Results The incidence of LVMI and LVH increased gradually with the increase of uric acid quartile [(114.41 ± 34.51), (121.34 ± 36.98), (126.86 ± 42.52), (141.74 ± 46.36) g / m 2, 35.0 %, 47.0%, 52.1% and 61.7%, respectively; all P <0.05], while there were significant differences in LVMI between male and female patients (144.12 ± 76.44, 132.58 ± 40.39 and 134.24 ± 41.00, (141.84 ± 55.02) g / m2; P <0.05]. There was no significant difference in the incidence of LVH between the two groups (57.1%, 50.2%, 54.3% and 52.7%, P> 0.05). Compared with women, male uric acid, LVMI increased, the incidence of LVH increased (P <0.05). Logistic regression analysis showed that uric acid was an independent risk factor for LVH in female patients [OR (95% CI) = 1.30 (1.13-1.56, P <0.01]. There was no significant correlation between uric acid and LVH in male patients P> 0.05). Conclusions Although the prevalence of uric acid and LVH in women with hypertension is lower than that in men, the uric acid is associated with LVH in female patients, while the correlation with male patients is not statistically significant.