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用家兔40只,分为正常对照组、胆固醇组、牛血清白蛋白组以及牛血清白蛋白加胆固醇组。造型4周处死,观察对比冠脉主干起始部、主动脉根、弓、胸部的病理形态变化。结果显示,牛血清白蛋白加胆固醇组动脉内膜厚度最大(P<0.05),泡沫细胞灶检出例数最多(P≤0.05),平滑肌细胞增生较明显,病变程度较重。表明急性免疫损伤与高胆固醇血症有协同作用,可能促进动脉粥样硬化早期病变的形成。
40 rabbits were divided into normal control group, cholesterol group, bovine serum albumin group and bovine serum albumin plus cholesterol group. The model was sacrificed at 4 weeks. The pathological changes of the aortic root, arch and chest were observed and compared. The results showed that the bovine serum albumin plus cholesterol group had the largest intimal thickness (P <0.05), the highest number of foam cell foci (P≤0.05), the more obvious proliferation of smooth muscle cells and the more severe lesions. Show that acute immune injury and hypercholesterolemia have a synergistic effect, may promote the formation of early atherosclerosis lesions.