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AIM:To evaluate the comparative therapeutic efficacy of radiofrequency ablation (RFA) and hepatic resection (HR) for solitary colorectal liver metastases (CLM).METHODS:A literature search was performed to identify comparative studies reporting outcomes for both RFA and HR for solitary CLM.Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects model.RESULTS:Seven nonrandomized controlled trials studies were included in this analysis.These studies included a total of 847 patients:273 treated with RFA and 574 treated with HR.The 5 years overall survival rates in the HR group were significantly better than those in the RFA group (OR:0.41,95% CI:0.22-0.90,P=0.008).RFA had a higher rate of local intrahe-patic recurrence compared to HR (OR:4.89,95% CI:1.73-13.87,P=0.003).No differences were found between the two groups with respect to postoperative morbidity and mortality.CONCLUSION:HR was superior to RFA in the treatment of patients with solitary CLM.However,the findings have to be carefully interpreted due to the lower level of evidence.
AIM: To evaluate the comparative therapeutic efficacy of radiofrequency ablation (RFA) and hepatic resection (HR) for solitary colorectal liver metastases (CLM). METHODS: A literature search was performed to identify comparative studies reporting outcomes for both RFA and HR for solitary CLM .Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either fixed effects models or random effects models. Seven nonrandomized controlled trials studies were included in this analysis. Patients: 273 treated with RFA and 574 treated with HR. 5-year overall survival rates in the HR group were significantly better than those in the RFA group (OR: 0.41, 95% CI: 0.22-0.90, P = 0.008) had a higher rate of local intrahepatic recurrence compared to HR (OR: 4.89, 95% CI: 1.73-13.87, P = 0.003) .No differences were found between the two groups with respect to postoperative morbidity and mortality. CONCLUSION: HR was superior to RFA in the tr eatment of patients with solitary CLM. However, the findings have to be calibrated due to the lower level of evidence.