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目的观察血必净注射液对严重肺挫伤患者外周血中血管内皮生长因子(VEGF)的影响。方法将60例严重肺挫伤患者根据治疗方法的不同分为观察组31例和对照组29例。对照组予常规综合治疗;观察组在对照组治疗基础上予血必净注射液治疗。应用酶联免疫吸附法分别检测入院第1、3、5、7天时2组血清VEGF水平,并比较相关临床指标全身炎性反应综合征(SIRS)发生情况,机械通气例数及时间,住院时间,72h内死亡例数及72h后死亡例数。结果 2组血清VEGF发病后即升高。对照组之后各时段逐渐升高;观察组血清VEGF伤后第1天开始逐渐下降,伤后第3、5、7天与对照组比较,差异均有统计学意义(P<0.01)。观察组SIRS发生率、机械通气使用率、72h内及72h后病死率均低于对照组,机械通气时间、住院时间均短于对照组,差异均有统计学意义(P<0.05或P<0.01)。结论血必净注射液能降低严重肺挫伤患者外周血VEGF水平,减轻其高表达所带来的肺损伤,明显改善患者预后,值得推广应用。
Objective To observe the effect of Xuebijing injection on vascular endothelial growth factor (VEGF) in peripheral blood of patients with severe pulmonary contusion. Methods Sixty patients with severe pulmonary contusion were divided into observation group (n = 31) and control group (n = 29) according to the different treatment methods. The control group was given conventional comprehensive treatment. The observation group was treated with Xuebijing injection on the basis of the control group. Serum VEGF levels were detected by enzyme-linked immunosorbent assay (ELISA) on the 1st, 3rd, 5th and 7th day after admission. The incidences of systemic inflammatory response syndrome (SIRS), the number of patients with mechanical ventilation and the time of hospital stay , The number of deaths within 72h and the number of deaths after 72h. Results Serum VEGF increased in both groups immediately after the onset of disease. The levels of VEGF in the observation group began to decrease gradually from the first day after injury, and the differences were statistically significant (P <0.01) on the 3rd, 5th, 7th day after injury compared with the control group. The incidence of SIRS and the rate of mechanical ventilation in observation group were lower than those in control group in 72h and 72h, the duration of mechanical ventilation and hospital stay were shorter than those in control group (P <0.05 or P <0.01) ). Conclusion Xuebijing Injection can reduce the level of VEGF in the peripheral blood of patients with severe pulmonary contusion, reduce the lung injury caused by its high expression and significantly improve the prognosis of patients, which is worth popularizing and applying.