论文部分内容阅读
1998年,美国明尼苏达州发现一种水痘-带状疱疹病毒突变株(VZV-MSP),该病毒的gE主要表面糖蛋白出现错义的突变。VZV-MSP突变导致gE外区B细胞表位缺失,该病毒突变株系与核苷酸多型性相关的有明显表型特性的病毒,而变异株则包括任何含核苷酸多型性的病毒,不管该病毒有无明显相关的表型。除VZV-MSP的gE突变外,核苷酸多型性与可区别的表型无关。
In 1998, a mutant of varicella-zoster virus (VZV-MSP) was found in Minnesota, United States, a missense mutation of the gE major surface glycoprotein of the virus. VZV-MSP mutations result in the deletion of B-cell epitopes in the gE outer region, which are viruses with pronounced phenotypic properties associated with nucleotide polymorphism, while the variant strains include any nucleotide polymorphism The virus, regardless of whether the virus has a significant correlation with the phenotype. In addition to the gE mutation of VZV-MSP, nucleotide polymorphisms are not associated with distinguishable phenotypes.