目的探讨辛伐他汀治疗不稳定型心绞痛(UAP)的临床疗效。方法112例UAP患者根据前瞻性、随机化原则分为观察组和对照组各56例,两组患者入院后均根据病情给予常规治疗,观察组在此基础上加用辛伐他汀,初始剂量为10mg,1次/d,睡前顿服,每4周调整1次剂量,最大剂量为40mg/d,睡前顿服,疗程2个月。疗程结束后观察两组临床疗效、心电图变化及药物不良反应。结果观察组显效率62.5%,总有效率96.4%;对照组显效率33.9%,总有效率69.6%;两组比较差异均有统计学意义,P<0.01。两组治疗期间均未出现明显不良反应,P>0.05。结论辛伐他汀具有明显的调脂作用及广泛的非调脂作用,可防止动脉粥样斑块进展,恢复血管内皮功能,抑制斑块中的炎症反应,稳定易损斑块,临床效果确切且不良反应少而轻微,值得临床推广应用。 Objective To investigate the clinical efficacy of simvastatin in the treatment of unstable angina pectoris (UAP). Methods One hundred and twelve UAP patients were divided into observation group and control group according to the principle of prospective and randomization. 56 patients in both observation group and control group were given routine treatment according to the condition. Simvastatin was added to the observation group on the basis of the initial dose 10mg, 1 time / d, Dayton clothing before going to bed, every 4 weeks to adjust the dose of 1, the maximum dose of 40mg / d, Dayton clothing before going to bed, treatment for 2 months. After the end of treatment, the clinical efficacy, ECG changes and adverse drug reactions were observed. Results The effective rate was 62.5% and the total effective rate was 96.4% in the observation group. The effective rate in the control group was 33.9% and the total effective rate was 69.6%. There was significant difference between the two groups (P <0.01). No significant adverse reactions occurred in both groups during treatment, P> 0.05. Conclusion Simvastatin has a significant lipid-lowering effect and a wide range of non-lipid-lowering effects, to prevent the progression of atherosclerotic plaque, restore endothelial function, inhibit the inflammatory response in plaque, stable vulnerable plaque, the clinical effect is exact Adverse reactions and minor, it is worth to promote clinical application.