Liquid Chromatography-Electrospray Quadrupole Linear Ion Trap Mass Spectrometric Method for Quantit

来源 :高等学校化学研究：英文版 | 被引量 : 0次 | 上传用户：xoyo7908114

【摘要】

：

A rapid,sensitive,and accurate method based on LC/MS/MS was developed and validated for the determination of domperidone in human plasma.Domperidone and interna

【作者】

：

WU Yi CHU Yang ZHANG Yun-hui W

【机构】

：

ResearchCenterforDrugMetabolism,CollegeofPharmacy

【出处】

：

高等学校化学研究：英文版

【发表日期】

：

2007年4期

【关键词】

：

中国人健康志愿者药物代谢动力学液相色谱-光谱法 Domperidone LC/MS/MS Pharmacokinetics

【基金项目】

：

Supported by the National Natural Science Foundation of China（ No. 39930180）.

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A rapid,sensitive,and accurate method based on LC/MS/MS was developed and validated for the determination of domperidone in human plasma.Domperidone and internal standard,tramadol,were extracted from plasma with diethyl ether-dichloromethane(60∶40,volume

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