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目的:观察鸦胆子油乳剂胸腔内注射治疗肺癌肺叶切除术后胸液过多的疗效和不良反应。方法:对80例肺癌肺叶切除术后第48-72小时胸液量>200 ml患者,随机分为治疗组和对照组,每组各40例治疗组患者采用经胸腔闭式引流管注入鸦胆子油乳剂30 ml,夹闭胸管24小时后观察疗效和不良反应,结果:治疗组40例中,术后第72-96小时胸液引流量<100 ml者37例,占92.5%;对照组40例中,术后第72-96小时胸液引流量<100 ml者8例,占20.0%;两组有统计学意义(P<0.05)。不良反应为发热(<38.5℃)2例,胃肠道反应2例,胸痛3例。结论:鸦胆子油乳剂治疗肺癌肺叶切除术后胸液过多疗效显著,不良反应轻。
Objective: To observe the curative effect and adverse reactions of Brucea javanica oil emulsion intrathoracic injection for the treatment of pleural effusion after lung cancer lobectomy. Methods: Eighty patients with pleural effusion> 200 ml 48-72 hours after lobectomy of lung cancer were randomly divided into treatment group and control group. 40 patients in each group received transcatheter closure of brucellosis Oil emulsion 30 ml, closed the chest tube 24 hours after the observation of efficacy and adverse reactions, the results: the treatment group 40 cases, 72-96 hours after the operation of pleural effusion volume <100 ml in 37 cases, accounting for 92.5%; control group In 40 cases, there were 8 cases (20.0%) of pleural fluid drainage volume <100 ml after 72-96 hours postoperatively. The two groups had statistical significance (P <0.05). Adverse reactions were fever (<38.5 ℃) in 2 cases, gastrointestinal reactions in 2 cases, chest pain in 3 cases. Conclusion: Brucea javanica oil emulsion treatment of lung cancer after lobectomy pleural effusion with significant effect, adverse reactions.