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目的观察感染日本血吸虫不同时间动物内脏中沉积虫卵的分布特征及组织病理变化。方法新西兰大白兔定量人工感染血吸虫后,比较感染后42、60 d沉积虫卵在组织中的分布特征、虫卵孵化率的变化以及相应部位的病理改变。结果感染42 d时,沉积虫卵百分比、每克组织沉积虫卵数及沉积虫卵孵化率最高的均为肝脏;感染60 d时,上述3个指标值最高的分别为肝脏、直肠和小肠上段。从感染后42 d到60 d,兔肝脏肿大,且由黑色逐渐变成暗灰色并失去弹性而硬化,小肠各段逐渐出现虫卵结节,结肠、盲肠和直肠可见黏膜充血、水肿、结节,病变程度与虫卵的沉积相关。结论新西兰大白兔感染日本血吸虫后不同时期,不同器官组织的沉积虫卵数量、密度及虫卵孵化率均有差异,且沉积虫卵的分布和宿主病理损伤程度有关。
Objective To observe the distribution and histopathological changes of sedimentary eggs in animal offal infected with Schistosoma japonicum at different times. Methods New Zealand white rabbits were infected by artificial infection with Schistosoma japonicum. The distribution characteristics of the deposited eggs in the tissues at 42 and 60 days after infection and the hatching rate of the eggs and pathological changes of the corresponding parts were compared. Results At 42 days after infection, the percentage of deposited eggs, the number of deposited eggs per gram of tissue and the hatching rate of deposited eggs were the highest. At 60 days after infection, the highest values of the above three indexes were the liver, rectum and upper intestine . From 42 days to 60 days after infection, the liver of the rabbits became swollen, and gradually became black and gray, and then hardened due to the loss of elasticity. Egg nodules gradually appeared in all stages of the small intestine. The colon, cecum and rectum showed mucosal congestion, edema and junction Festival, the degree of disease and the deposition of eggs related. Conclusions New Zealand white rabbits infected with Schistosoma japonicum in different periods, the number of eggs deposited in different organs and the hatching rate of eggs are different, and the distribution of deposited eggs and host pathological damage degree.