目的　探讨桩蛋白 (PAX)和血管内皮生长因子 (VEGF)在人肺部组织中的表达及其与组织学类型、组织学分级、淋巴结转移及预后的关系。方法　应用免疫组化的方法检测 79例肺癌组织中PAX和VEGF表达的情况。结果　 1、79例肺癌组织PAX和VEGF的阳性率为 3 4 1%和 64 6% ;2、PAX的阳性率与肺癌的淋巴结呈正相关 (P <0 0 5 ) ,与 2年生存率无关 (P >0 0 5 ) ;3、VEGF的阳性率与淋巴结转移呈正相关 (P <0 0 1) ,与 2年生存率呈负相关 (P <0 0 1)。结论　PAX和VEGF在肺癌的转移中有重要作用 ;VEGF还影响着肺癌的预后 Objective To investigate the expression of paxillin (PAX) and vascular endothelial growth factor (VEGF) in human lung tissue and its relationship with histological type, histological grade, lymph node metastasis and prognosis. Methods The expression of PAX and VEGF in 79 cases of lung cancer was detected by immunohistochemistry. Results The positive rates of PAX and VEGF in lung cancer tissues were 34.1% and 64.6% respectively. The positive rate of PAX was positively correlated with the lymph nodes of lung cancer (P <0.05), but not with the 2-year survival rate P> 0.05). 3. The positive rate of VEGF was positively correlated with lymph node metastasis (P <0.01), and negatively correlated with 2-year survival rate (P <0.01). Conclusion PAX and VEGF play an important role in the metastasis of lung cancer. VEGF also affects the prognosis of lung cancer