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卵巢癌是妇科常见恶性肿瘤之一,病死率居妇科肿瘤之首。因早期多无明显症状体征且缺乏敏感和特异的筛选手段,70%以上的患者发现时已为晚期,多伴有腹水、盆腹腔广泛转移,恶性程度高,预后极差,故卵巢癌的早发现早诊断在提高生存率方面显得尤为重要。近年表观遗传学的研究进展迅速,在卵巢癌发生发展治疗等方面具有重要的指导意义,为卵巢癌的早期诊断、优化治疗、改善预后指明新方向。DNA甲基化是最常见也是目前研究最清楚的表观遗传修饰形式,能引起染色质结构、DNA构象、DNA稳定性及DNA与蛋白质相互作用方式的改变,调控基因表达,在肿瘤的发生发展中扮演重要角色。就DNA甲基化在卵巢癌表观遗传学中的研究进展作一综述。
Ovarian cancer is one of the common gynecological malignancies, mortality in the first gynecologic cancer. More than 70% of the patients were found late due to early symptoms and lack of sensitive and specific screening measures, with ascites, extensive abdominal metastasis, high malignancy and poor prognosis, so early ovarian cancer Early diagnosis found to be particularly important in improving the survival rate. In recent years, the research on epigenetics has progressed rapidly and has an important guiding significance in the development and treatment of ovarian cancer. It provides a new direction for the early diagnosis, optimal treatment and prognosis of ovarian cancer. DNA methylation is the most common and most clearly studied form of epigenetic modification. It can cause changes in chromatin structure, DNA conformation, DNA stability and the interaction between DNA and protein, regulate gene expression in the development of tumors Play an important role. The progress of DNA methylation in epigenetics of ovarian cancer is reviewed.