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目的探讨糖代谢异常患者肾功能损害对冠状动脉病变的影响。方法选择确诊的糖代谢异常并诊断为冠心病患者70例,作为冠心病组,选择确诊的糖代谢异常但冠状动脉狭窄程度均<50%的患者60例,作为对照组。所有患者进行生化指标检测、冠脉造影及病变评分、统计学处理,比较两组患者实验室指标、冠心病病变支数与尿白蛋白微量/尿肌酐(UACR)的相关性。结果冠心病组患者收缩压、空腹血糖、糖化血红蛋白、UACR明显高于对照组,差异有统计学意义(P<0.05)。单支病变、双支病变、三支病变分别为18例、37例、15例,对应UACR分别为(3.2±1.8)mg/mmol、(4.3±1.9)mg/mmol、(6.4±3.3)mg/mmol。结论 UACR的升高与糖代谢异常患者发生冠心病呈正相关。
Objective To investigate the effects of renal dysfunction on coronary lesions in patients with abnormal glucose metabolism. Methods Seventy patients with coronary artery disease who were diagnosed as abnormal glucose metabolism and diagnosed as coronary heart disease were selected as the coronary heart disease group. Sixty patients with abnormal glucose metabolism but less than 50% of coronary artery stenosis were selected as the control group. All patients were biochemical markers, coronary angiography and lesion score, statistical analysis, compared the two groups of laboratory indicators, coronary lesions and urinary albumin micro / urinary creatinine (UACR) correlation. Results The systolic blood pressure, fasting blood glucose, glycosylated hemoglobin and UACR in CHD group were significantly higher than those in control group (P <0.05). The single-vessel, double-vessel, and triple-vessel lesions were 18, 37 and 15 respectively, with corresponding UACRs of (3.2 ± 1.8) mg / mmol and (4.3 ± 1.9) mg / mmol and (6.4 ± 3.3) mg / mmol. Conclusions UACR is positively correlated with coronary heart disease in patients with abnormal glucose metabolism.