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本文报告22例心衰病人安静状态下的血浆去甲肾上腺素水平及心缩间期(STI)。发现心衰患者去甲肾上腺素水平与左室射血时间(LVET)呈显著负相关(r=-0.443,p<0.025),与射血前期时间(PEP)/LVET比值呈正相关(r=0.435,p<0.025)。10例心衰病人接受可乐宁治疗一周后去甲肾上腺素水平显著降低,LVET延长,PEP缩短,PEP/LVET比值减小。提示心衰病人交感功能过度增强,血管阻力增高,左室功能降低。
This article reports the plasma norepinephrine levels and the systolic interval (STI) in 22 patients with heart failure under quiescent conditions. There was a significant negative correlation between norepinephrine and left ventricular ejection time (LVET) (r = -0.443, p <0.025) and a positive correlation with PEP / LVET (r = 0.435 , p <0.025). One week after treatment with clonidine in 10 patients with heart failure, norepinephrine was significantly decreased, LVET prolonged, PEP shortened and PEP / LVET decreased. Prompt sympathetic heart failure patients over-enhanced vascular resistance increased left ventricular function decreased.