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糖尿病长期良好的控制,能否减少其并发症的发生,曾有动物实验及临床的回顾性研究作了肯定性答复;但迄今仍未见具有说服力的报告。近期的研究表明,长期糖代谢紊乱引起大量有害代谢产物如高级糖基化蛋白终末产物(advanced glycosylation endproducts,AGEs)的体内堆积,胰岛素使用不当引起的胰岛素体内积蓄或缺乏,胰岛素基因和胰岛素受体基因突变引起的胰岛素抵抗,在糖尿病性视网膜病变(diabetic retinopathy,DR)发生和发展中起着重要作用。本文着重综述糖尿病控制变化与 DR 的关系。
Long-term good diabetes control, can reduce the incidence of complications, animal experiments and clinical retrospective studies have been affirmative response; but so far there is no convincing report. Recent studies have shown that long-term glucose metabolism disorders cause in vivo accumulation of a large number of harmful metabolites such as advanced glycosylation endproducts (AGEs), in vivo insulin accumulation or deficiency due to inappropriate insulin use, insulin gene and insulin receptor Insulin resistance induced by somatic mutation plays an important role in the development and progression of diabetic retinopathy (DR). This article highlights the relationship between changes in diabetes control and DR.