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小鼠用~(6O)Co-γ射线全身照射600rad。照后立即和照后第2—12天期间每两天每只小鼠腹腔注射碳酸锂0.2mg。每隔5天,用药组和对照组各活杀小鼠10只,取外周血和脾脏作WBC、RBC、血小板和脾重指数等检查。结果表明,在照射后的第5、10、20、25、30天,用药组的WBC数量比对照组分别升高了6.6%、20.8%、46 8%、64.5%、52.0%(P<0.01)。脾重指数的增加也类似于WBC的变化。所以,锂对于预防和治疗因辐射损伤所引起的白细胞减少症可能是个有希望的药物。
Mice with ~ (6O) Co-γ-ray irradiation 600rad whole body. Immediately after irradiation and every 2 to 12 days after irradiation, each mouse was intraperitoneally injected with 0.2 mg of lithium carbonate. Every 5 days, 10 mice were killed and killed in the treatment group and the control group respectively. The peripheral blood and spleen were taken as WBC, RBC, platelet and spleen mass index. The results showed that the number of WBC in treatment group increased by 6.6%, 20.8%, 46.8%, 64.5% and 52.0% (P <0.01) on the 5th, 10th, 20th, ). The increase in spleen mass index is also similar to changes in WBC. Therefore, lithium may be a promising drug for the prevention and treatment of leukopenia caused by radiation damage.