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我们曾从△~(9(11))一雌二醇合成11β-羟基-雌二醇。现报道如下改进合成路线; 该路线用酰化法保护3-羟基,用重铬酸吡啶盐(简称PDC)氧化11α-羟基(17-羟基同时被氧化)均分别较原路线苄醚化保护和Moffett氧化收率
We have from the △ ~ (9 (11)) a-estradiol synthesis 11β-hydroxy-estradiol. Now reported as follows to improve the synthetic route; the route acylation method to protect the 3-hydroxy, pyridinium dichromate (PDC) oxidation of 11α-hydroxy (17-hydroxyl oxidation at the same time) were compared with the original route of benzyl etherification and Moffett oxidation yield