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AIM: To investigate the correlation between hepatic osteodystrophy and osteoporosis in patients with liver cirrhosis. METHODS: Bone mineral density of the patients (n = 55) and that of the control group (n = 30) were measured by dual-energy X-ray absorptiometry. All the women in the study were premenopausal. Deoxypyridinoline, pyridinoline and urinary Ca 2+ were measured as bone destruction markers, while alkaline phosphatase (ALP), osteocalcin and insulin-like growth factor-1 (IGF-1) were measured as bone formation markers. Furthermore, interleukin-1 (IL-1), IL-6, tumor necrosis factor α (TNF-α), vitamin D3, direct bilirubin, albumin, cortisol and parathyroid hormone (PTH) levels were measured. The independent Student t test and χ 2 test were employed in comparing both groups, and the Pearson correlation test was used to determine associations. RESULTS: Comparing cirrhosis and control groups, lumbar total T-score (-1.6 ± 1.2 g/cm 2 vs -0.25 ± 1.3 g/cm 2 , P < 0.001), lumbar total Z-score (-1.2 ± 1.23 g/cm 2 vs -0.6 ± 1.3 g/cm 2 , P < 0.001), total femur T-score (-0.05 ± 1 g/cm 2 vs -0.6 ± 0.9 g/cm 2 , P = 0.003) and total femur Z-score (-0.08 ± 1.5 g/cm 2 vs 0.7 ± 0.9 g/cm 2 , P =0.003) showed significantly lower values in the cirrhosis group. Blood ALP level (109.2 ± 57 U/Lvs 62.6 ± 32.5 U/L, P < 0.001), IL-6 level (27.9 ± 51.6 pg/mL vs 3.3 ± 3.1 pg/mL, P = 0.01), TNF-α level (42.6 ± 33.2 pg/mL vs 25.3 ± 12.3 pg/mL, P = 0.007) and direct bilirubin level (0.9 ± 0.7 mg/dL vs 0.3 ± 0.2 mg/dL, P < 0.001) were significantly higher in the cirrhosis group. IGF-1 level (47.7 ± 26.2 ng/mL vs 143.4 ± 53.2 ng/mL, P < 0.001), osteocalcin level (1.05 ± 2.5 ng/mL vs 7.0 ± 13 ng/mL, P = 0.002) and 24 h urinary Ca 2+ (169.6 ± 227.2 mg/dL vs 287 ± 168.6 mg/dL, P = 0.003) were significantly lower in the cirrhosis group. Urinary deoxypyridinoline/creatinine (9.4 ± 9.9 pmol/μmol vs 8.1 ± 5.3 pmol/μmol, P = 0.51), urinary pyridinoline/creatinine (51.3 ± 66.6 pmol/μmol vs 29 ± 25.8 pmol/μmol, P = 0.08), blood IL-1 level (3.4 ± 8.8 pg/mL vs 1.6 ± 3.5 pg/mL, P = 0.29), vitamin D3 level (18.6 ± 13.3 μg/L vs 18.4 ± 8.9 μg/L, P = 0.95), cortisol level (11.1 ± 4.8 μg/dL vs 12.6 ± 4.3 μg/dL, P = 0.15) and PTH level (42.7 ± 38 μg/dL vs 34.8 ± 10.9 μg/dL,P = 0.27) were not significantly different. CONCLUSION: Hepatic osteodystrophy is an important complication encountered in patients with liver cirrhosis and all patients should be monitored for hepatic osteodystrophy.
A: To investigate the correlation between hepatic osteodystrophy and osteoporosis in patients with liver cirrhosis. METHODS: Bone mineral density of the patients (n = 55) and that of the control group (n = 30) were measured by dual-energy X- ray all the women in the study were premenopausal. Deoxypyridinoline, pyridinoline and urinary Ca 2+ were measured as bone destruction markers, while alkaline phosphatase (ALP), osteocalcin and insulin-like growth factor-1 (IGF- bone formation markers. Furthermore, interleukin-1 (IL-1), IL-6, tumor necrosis factor α (TNF- α), vitamin D3, direct bilirubin, albumin, cortisol and parathyroid hormone Student t test and χ 2 test were taken in comparing both groups, and the Pearson correlation test was used to determine associations. RESULTS: Comparing cirrhosis and control groups, lumbar total T-score (-1.6 ± 1.2 g / cm 2 vs -0.25 ± 1.3 g / cm 2, P <0.001), lumbar total Z-score (-1.2 ± 1.23 g / cm 2 vs. -0.6 ± 1.3 g / cm 2, P <0.001), total femur T-score (-0.05 ± 1 g / cm 2 vs -0.6 ± 0.9 g / cm 2 , P = 0.003) and total femur Z-score (-0.08 ± 1.5 g / cm 2 vs 0.7 ± 0.9 g / cm 2, P = 0.003) showed significant lower values in the cirrhosis group. / Lvs 62.6 ± 32.5 U / L, P <0.001), IL-6 level (27.9 ± 51.6 pg / mL vs 3.3 ± 3.1 pg / mL, P = 25.3 ± 12.3 pg / mL, P = 0.007) and direct bilirubin level (0.9 ± 0.7 mg / dL vs 0.3 ± 0.2 mg / dL, P <0.001) were significantly higher in the cirrhosis group. osteocalcin level (1.05 ± 2.5 ng / mL vs 7.0 ± 13 ng / mL, P = 0.002) and 24 h urinary Ca 2+ (169.6 ± 227.2 mg / Urinary deoxypyridinoline / creatinine (9.4 ± 9.9 pmol / μmol vs 8.1 ± 5.3 pmol / μmol, P = 0.51), urinary pyridinoline / creatinine (dL vs 287 ± 168.6 mg / 51.3 ± 66.6 pmol / μmol vs 29 ± 25.8 pmo, blood IL-1 level (3.4 ± 8.8 pg / mL vs 1.6 ± 3.5 pg / mL, P = 0.29), vitamin D3 level (18.6 ± 13.3 μg / L vs 18.4 ± 8.9 μg / P = 0.95), cortisol level (11.1 ± 4.8 μg / dL vs 12.6 ± 4.3 μg / dL, P = 0.15) and PTH level (42.7 ± 38 μg / dL vs 34.8 ± 10.9 μg / dL, P = 0.27) were not significantly different. CONCLUSION: Hepatic osteodystrophy is an important complication encountered in patients with liver cirrhosis and all patients should be monitored for hepatic osteodystrophy.