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骨桥蛋白(OPN)是一种多效性的结合蛋白,可作为致炎因子参与多种自身免疫性疾病发病。OPN在不同临床类型多发性硬化(MS)患者血浆中的水平有所不同,OPN在损伤过程中不同程度的表达与疾病的严重程度密切相关,且在动物模型实验性变态反应性脑脊髓炎(EAE)研究中同样发现,OPN是发病关键因子之一。OPN在MS及其EAE发病机制中起着重要作用,可能与OPN作为一种免疫应答的诱导物,影响Th1/Th2平衡,调节IL-10、IL-12、肿瘤坏死因子α等细胞因子的释放有关。研究OPN的作用将有助于MS发病机制的探索,并且为临床治疗提供新思路。
Osteopontin (OPN) is a pleiotropic binding protein that is involved in the pathogenesis of many autoimmune diseases as an inflammatory cytokine. The levels of OPN in different clinical types of patients with multiple sclerosis (MS) are different. The expression of OPN in different stages of the injury is closely related to the severity of the disease. In animal models of experimental allergic encephalomyelitis EAE) study also found that OPN is one of the key factors in the pathogenesis. OPN plays an important role in the pathogenesis of MS and its EAE. It may play an important role in the pathogenesis of MS and its EAE. It may be related to OPN as an inducer of immune response, affecting the balance of Th1 / Th2 and regulating the release of cytokines such as IL-10, IL-12 and tumor necrosis factor related. The study of the role of OPN will help explore the pathogenesis of MS, and provide new ideas for clinical treatment.