The paper introduces firstly the seismic loss assessment method based on macro-economic indicators and new vulnerability models determined by the data from the on-site damage and loss survey to earthquakes occurred in China during the last two decades.The fast assessment for the 2008 Wenchuan earthquake with MS8.0 is given based on an empirical intensity attenuation relationship.Compared with the assessment based on the practical seismic intensity map of the event according to the on-site investigation, the result demonstrates the usability of the seismic vulnerability models introduced in the paper.In addition, it is indicated that the main uncertainty of losses in the fast loss assessment comes from the uncertainty of the estimation of seismic ground motion. The paper introduces first the seismic loss assessment method based on macro-economic indicators and new vulnerability models determined by the data from the on-site damage and loss survey to earthquakes occurred in China last the last two decades. The fast assessment for the 2008 Wenchuan earthquake with MS8.0 is given based on an actual intensity map of the event based on the practical seismic intensity map of the event according to the on-site investigation, the result demonstrates the usability of the seismic vulnerability model introduced in the In addition, it is indicated that the main uncertainty of losses in the fast loss assessment comes from the uncertainty of the estimation of seismic ground motion.