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据报导妊娠期母亲血清及羊水中甲胎蛋白水平下降与胎儿先天愚型(Down’s综合征)有关。这种关系的理由尚不清楚,但我们曾认为这可能与Down’s综台征受累胎儿产生的甲胎蛋白量减少有关。为了进一步探讨这种可能性,我们从Down’s综合征及对照组的新生儿中采集脐带血清测量了甲胎蛋白的浓度。 在牛津的John。Radcliffe医院, 自1973年6月～1978年3月期间出生的新生儿中常规采集脐带血作为较大规模的围产期流行病学研究的一部分。血清于-40℃低温下储存。我们从储存的脐带血清中找出了22例曾在我们以前的资料中确定为Down’s综合征婴儿的血清标本,并为每个病例找了3例对照,对病
It is reported that the decrease of alpha-fetoprotein level in the mother’s serum and amniotic fluid during pregnancy is related to the Down’s syndrome. The rationale for this relationship is unclear, but we thought it might be related to a decrease in the amount of alpha-fetoprotein produced by fetuses with Down’s syndrome. To further explore this possibility, we measured umbilical cord serum from Down’s Syndrome and control neonates and measured the concentration of alpha-fetoprotein. John at Oxford. Radcliffe Hospital, which routinely collected cord blood from newborns born between June 1973 and March 1978 as part of a larger-scale perinatal epidemiological study. Serum stored at -40 ℃ low temperature. We collected 22 serum samples of infant identified as Down’s syndrome in our previous data from stored umbilical cord serum and found 3 controls for each case,