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软化和扩张子宫颈在人工流产和引产中是一个重要的临床问题。口服单次或多次剂量的mifepristone(RU486)25～600mg可扩张子宫颈管,减轻宫颈强直,有利于宫颈的器械扩张,但作用机制尚不明。故通过评价RU486对服用过环氧合酶抑制剂——萘普生的妊娠妇女的宫颈软化效应来验证这一假说:RU486对宫颈管的作用是改变体内雌激素和孕激素的局部平衡,使前列腺素样合成
Softening and expanding Cervix is an important clinical problem in induced abortion and induction of labor. Oral single or multiple doses of oral mifepristone (RU486) 25 ~ 600mg can expand the cervical canal, reduce cervical stiffness, is conducive to the expansion of cervical instruments, but the mechanism is not yet clear. This hypothesis is verified by evaluating the cervical softening effect of RU486 on pregnant women taking the cyclooxygenase inhibitor naproxen: The effect of RU486 on the cervical canal is to alter the local balance of estrogen and progestin in the body so that Prostaglandin-like synthesis