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目的 为了研究健康儿童对国产乙肝疫苗的免疫应答。方法 筛选8～10岁健康儿童,按免疫程序接种乙肝疫苗,于首次接种后的规定时间采集静脉血,用SPRIA固相放射免疫测定法检测抗-HBs消长水平。结果 乙肝疫苗全程免疫后,时点有效应答率为95.83％,人群免疫后随着时间的推移,转阴率不断增加,尤以低、中应答组为著。结论 不同应答产生抗体水平与抗-HBs降到10mIU/ml以下的时间成正相关,与时点抗体高低成负相关,故可根据全程免疫后,时点抗体水平来安排加强接种。
Objective To study the immune response of healthy children to domestic hepatitis B vaccine. Methods The healthy children aged 8 to 10 years were screened. Hepatitis B vaccine was inoculated according to the immunization schedule. Venous blood was collected at the prescribed time after the first vaccination. The level of anti-HBs was detected by SPRIA radioimmunoassay. Results After the whole course of Hepatitis B vaccine immunization, the effective response rate was 95.83%. After the immunization, the rate of negative conversion increased with the passage of time, especially in low and middle response groups. Conclusions The level of antibody produced by different responses is positively correlated with the time when the anti-HBs is reduced to below 10mIU / ml, and is negatively correlated with the level of the antibodies at the time point. Therefore, vaccination can be arranged according to the level of antibody after the whole immunization.