近年,在妊高征的病理变化上,明确了凝血(口恶)烷A_2(TXA_2)作用增强使PGI_2/TXA_2生理平衡被破坏有重大意义。理论上妊高征的治疗可用增强PGI_2作用的方法来恢复PGI_2/TXA_2的平衡。应用PGI_2制剂后虽有降压作用,但出现心率增快、潮热充血、头痛及引发宫缩等副作用,且不能预防胎儿发育迟缓及胎儿窘迫等,也不能改善胎儿胎盘循环,所以后来临床上基本不再用该制剂。作者从内科、脑外科应用 In recent years, in the pathological changes of PIH, it is clear that the increase of TXA_2 effect of coagulant (TXA_2) makes the PGI_2 / TXA_2 physiological balance destroyed. In theory, treatment of PIH can restore PGI_2 / TXA_2 balance by increasing PGI_2. PGI_2 although the application of antihypertensive effect, but there is increased heart rate, hot flashes, headache and contractions and other side effects caused, and can not prevent fetal growth retardation and fetal distress, etc., can not improve fetal placental circulation, so later clinically The basic no longer use the preparation. The author from the internal medicine, brain surgery applications