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以血凝法测定222例乙型肝炎病毒(HBV)感染者血清多聚白蛋白受体(pHSA-R)结合活性。其中166例慢乙肝pHSA-R结合活性阳性率为39.8％;56例携带者翔7.5％。另50例健康对照者为2.0％(P<0.001)。pHSA-R阳性者中有92.6％患者的HBsAg≥1:256。HBsAg≥1:256的患者pHSA-R的几何平均滴度±标准差(GMT±SD)为58.83±5.04;HBsAg<1:256者为11.31±0.55。83.1％pHSA-R阳性患者的血清HBV DNA亦为阳性(P<0.001)。72.2％HBeAg阳性患者的pHSA-R为阳性(P<0.001)。结果提示,pHSA-R结合活性的检测充分反映了HBV的复制活性和HBV感染者血清的感染性。
Serum poly-albumin receptor (pHSA-R) binding activity in 222 patients with hepatitis B virus infection was determined by hemagglutination assay. The positive rate of pHSA-R binding activity of 166 chronic hepatitis B patients was 39.8%, while that of 56 patients was 7.5%. The other 50 healthy controls were 2.0% (P <0.001). 92.6% of patients with pHSA-R positive had HBsAg ≥1: 256. The geometric mean titer ± standard deviation (GMT ± SD) of pHSA-R was 58.83 ± 5.04 for patients with HBsAg ≥ 1: 256 and 11.31 ± 0.55.83.1% for patients with pHSA-R positive for HBsAg <1: 256 Also positive (P <0.001). 72.2% of HBeAg-positive patients had positive pHSA-R (P <0.001). The results suggest that the detection of pHSA-R binding activity fully reflects the replication activity of HBV and the sera of patients with HBV infection.