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Type 1 diabetes mellitus(T1DM) as one of the most well-known autoimmune disease, results from the destruction of β-cells in pancreas by autoimmune process. T1 DM is fatal without insulin treatment. The expansion of alternative treatment to insulin is a dream to be fulfilled. Currently autoimmunity is considered as main factor in development of T1 DM. So manipulation of the immune system can be considered as alternative treatment to insulin. For the past decades, vitamin A has been implicated as an essential dietary micronutrient in regulator of immune function. Despite major advantage in the knowledge of vitamin A biology, patients who present T1 DM are at risk for deficiency in vitamin A and carotenoids. Applying such evidences, vitamin A treatment may be the key approach in preventing T1 DM.
Type 1 diabetes mellitus (T1DM) as one of the most well-known autoimmune diseases, results from the destruction of beta-cells in pancreas by autoimmune process. T1 DM is fatal without insulin treatment. The expansion of alternative treatment to insulin is a dream To be fulfilled. Currently autoimmunity is considered as main factor in development of T1 DM. So manipulation of the immune system can be considered as alternative treatment to insulin. For the past decades, vitamin A has been implicated as an essential dietary micronutrient in regulator of Despite the advantage in the knowledge of vitamin A biology, patients who present T1 DM are at risk for deficiency in vitamin A and carotenoids. Applying such evidences, vitamin A treatment may be the key approach in preventing T1 DM.