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目的研究甲地孕酮防治肿瘤化疗中白细胞减少的疗效和对患者生活质量的影响。方法100例肿瘤患者被随机分为研究组(50例)和对照组(50例),对照组:地榆升白片4片/次,3次/d,全程口服。研究组:地榆升白片4片/次,3次/d,全程口服;甲地孕酮160mg,1次/d,连用10d,自化疗第1天早晨口服,3周为1周期,两周期后评价患者白细胞减少的程度及生活质量。结果研究组和对照组白细胞减少发生率分别为50.0%和72.0%,差异有显著性(P<0.05)。Ⅲ度以上减少发生率分别为12.0%和26.0%(P>0.05)。食欲降低发生率分别为58.0%和90.0%(P<0.01),Karnofsky未下降比率分别为90.0%和52.0%(P<0.01),体重增加比率分别为86.0%和38.0%(P<0.01)。两组疼痛减轻比率分别为72.0%和56.0%(P>0.05)。结论在肿瘤化疗中,甲地孕酮能够明显缓解肿瘤化疗中白细胞减少,同时明显提高患者生活质量。
Objective To study the effect of megestrol on the prevention and treatment of neutropenia in cancer chemotherapy and the quality of life of patients. Methods 100 patients with cancer were randomly divided into the study group (50 cases) and the control group (50 cases), the control group: Burmese rose white tablets 4 times / times, 3 times / d, the whole oral. Study group: Burnet rose white tablets 4 times / times, 3 times / d, the whole oral; megesterone 160mg, 1 / d, once every 10d, since the first day of chemotherapy oral, 3 weeks for a cycle, two After the cycle evaluation of patients with leukopenia and quality of life. Results The incidence of leukopenia in study group and control group was 50.0% and 72.0%, respectively, with significant difference (P <0.05). Ⅲ degree or more reduce the incidence rates were 12.0% and 26.0% (P> 0.05). The incidence of appetite reduction was 58.0% and 90.0%, respectively (P <0.01). The non-decreasing Karnofsky rates were 90.0% and 52.0% (P <0.01), and the weight gain rates were 86.0% and 38.0%, respectively. The pain relief rates in both groups were 72.0% and 56.0%, respectively (P> 0.05). Conclusion In the chemotherapy of tumor, megestrol can obviously reduce leukopenia in the chemotherapy of the tumor and improve the quality of life of the patients.