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本文报道5例长期有丙氧鸟苷(ganciclovir)治疗免疫缺陷综合征(AIDS)患者的巨细胞病毒(CMV)视网膜炎时,发生精神改变和死亡,尸检证实患活动性CMV脑炎。 1989年6月至1992年2月,收治5例女性同性恋AIDS患者,均以叠氮胸苷(Zidovudine)维持治疗,因患危及视力的CMV视网膜炎,静脉给予丙氧鸟苷5mg/kg/12小时,诱导期14天,以后每周6天治疗,5或6mg/kg/日。自确诊CMV视网膜炎至死亡平均8.3个月,死前有3～6周的精神状态改变:即昏睡,精神错乱和最后抑制。除1例表现
This article reports the mental changes and deaths of 5 cases of cytomegalovirus (CMV) retinitis in ganciclovir patients treated with ganciclovir for a long time, and confirms the presence of active CMV encephalitis on autopsy. From June 1989 to February 1992, five female patients with homosexual AIDS were admitted, all of whom were treated with Zidovudine. CMV retinopathy with endophthalmitis was intravenously administered with 5 mg / kg / Hour, induction period 14 days, thereafter 6 days a week, 5 or 6 mg / kg / day. Since the diagnosis of CMV retinitis to death an average of 8.3 months, 3 to 6 weeks before death, mental state changes: namely lethargy, confusion and the final inhibition. In addition to 1 case performance