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目的:分析甲状腺功能5项检测在妊娠期妇女中的应用价值,为制定妊娠期妇女的甲状腺功能指标的参考值范围提供依据。方法:选取2013年8月~2014年12月我院收治的826例健康妊娠妇女(实验组)与794例非妊娠育龄妇女(对照组)为研究对象。采用电化学发光法检测甲状腺功能5项指标,即三碘甲腺原氨酸(TT3)、甲状腺素(TT4)、促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4),比较两组甲状腺功能异常率,并比较5项指标在妊娠早、中、晚期妇女与对照组中的差异。结果:(1)实验组甲状腺功能异常的发生率(39.10%)显著高于对照组(17.63%),差异有统计学意义(P<0.05);(2)实验组FT4、TT4水平随着妊娠期的进展逐渐降低,TSH水平逐渐升高,且均低于对照组水平,差异有统计学意义(P<0.05);而各妊娠期FT3、TT3水平比较差异无统计学意义,但均略低于对照组(P>0.05)。结论:甲状腺功能5项指标检测应作为妊娠期妇女的孕期必查项目之一,且制定早、中、晚期妊娠期妇女的甲状腺功能5项指标参考值范围十分必要。
Objective: To analyze the value of 5 tests of thyroid function in pregnant women and provide the basis for setting reference value range of thyroid function index in pregnant women. Methods: A total of 826 healthy pregnant women (experimental group) and 794 non-pregnant women of childbearing age (control group) admitted to our hospital from August 2013 to December 2014 were selected as the study objects. Five indicators of thyroid function were detected by electrochemiluminescence, namely TT3, TT4, TSH, FT3, Thyroxine (FT4) was used to compare the rates of thyroid dysfunction in the two groups. The differences of the five indexes in the early, middle and late pregnancy women and the control group were compared. Results: (1) The incidence of thyroid dysfunction in the experimental group (39.10%) was significantly higher than that in the control group (17.63%), the difference was statistically significant (P <0.05); (2) (P <0.05). However, the levels of FT3 and TT3 in each pregnancy were not significantly different, but both were lower than those in the control group In the control group (P> 0.05). Conclusion: The detection of 5 indexes of thyroid function should be one of the items to be checked during pregnancy, and it is necessary to draw up the reference value of 5 indexes of thyroid function in women with early, middle and late pregnancy.