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高温(hyperthermia)定义为高于正常体温的温度。高温治疗癌瘤约始于1866年,当时Busch注意到丹毒所致长期发热后面部肉瘤退行。作为抗癌方法。自二十世纪早期起,高温即成为广泛的临床和实验室研究的课题。通常认为所有细胞可为高温治疗所杀灭。新生物组织往往有过多但无效的血管腔道而相对缺氧并酸中毒,当遭受热的袭击时,本身冷却的能力不足,因而热量积存,恶性组织则积热更多。如高热剂量(温度×时间)足够大,正常组织的冷却机制亦将受限。结果正常细胞也将死亡。
Hyperthermia is defined as a temperature higher than normal body temperature. The hyperthermia treatment of cancers began around 1866, when Busch noted that erysipelas caused a long-term fever and that the back sarcoma regressed. As an anti-cancer method. Since the early 20th century, high temperatures have become the subject of extensive clinical and laboratory research. It is generally believed that all cells can be killed by hyperthermia treatment. New biological tissues often have too many but ineffective vascular lumens and relatively lack of oxygen and acidosis. When subjected to heat attacks, their ability to cool themselves is insufficient, so the heat builds up, and malignant tissue accumulates more heat. If the high thermal dose (temperature × time) is large enough, the cooling mechanism of normal tissue will also be limited. As a result, normal cells will also die.