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Wnt信号转导途径可以分为决定细胞命运的经典途径和控制细胞运动及组织极性的非经典途径。经典WNT信号转导通路是Wnt蛋白通过与Frizzled(FZD)家族特异受体和LRP5/LRP6辅助受体结合,触发细胞内的信号转导,使β-连环蛋白(β-catenin)聚集的级联反应过程。非经典的Wnt信号被转导是通过Frizzled家族受体和ROR2/RYK联合受体结合到Dishevelled依赖(Rho family GTPases和c-junNH2-terminal kinase)或Ca2+依赖的信号级联反应。Wnt通路及其有关的其他通路在胚胎发育和肿瘤发生中起重要作用。在许多种人类癌病中,Wnt通路的负性调节基因突变失活。经优化选择分离出的择靶向作用于WNT信号途径的小分子复合物和人类单克隆抗体可以用于癌症的治疗。
The Wnt signaling pathway can be divided into a classical pathway that determines cell fate and a non-classical pathway that controls cell motility and tissue polarity. The classic WNT signaling pathway is a cascade of Wnt proteins that aggregate beta-catenin by triggering intracellular signal transduction by binding to the Frizzled (FZD) family-specific receptor and the LRP5 / LRP6 co-receptor reaction process. Non-canonical Wnt signaling is mediated through the binding of the Frizzled family receptor and the ROR2 / RYK co-receptor to Dishevelled-dependent (Rho family GTPases and c-junNH2-terminal kinase) or Ca2 + -dependent signaling cascades. Wnt pathway and other related pathways play an important role in embryonic development and tumorigenesis. Negative regulatory mutations in the Wnt pathway are inactivated in many human cancers. The small molecule complexes targeting human WNT signaling and the human monoclonal antibodies isolated by optimized selection can be used in the treatment of cancer.