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目的探讨布地奈德混悬液(普米克令舒)和利巴韦林联合雾化吸入治疗毛细支气管炎的临床效果。方法 86例毛细支气管炎患儿随机分为治疗组与对照组各43例。布地奈德混悬液(普米克令舒),剂量为0.5～1mg和利巴韦林注射液50mg/次;对照组:α-糜蛋白酶5mg/次。每组药物均加入生理盐水5ml稀释以空气压缩泵雾化吸入,2次/d,5～10min/次,连用5～7d。观察各组咳嗽、喘憋、气促、哮鸣音和湿啰音好转情况及不良反应?峁?总有效率治疗组和对照组比较差异均有统计学意义(χ2=4.63,P<0.05)。喘憋消失、气促缓解、哮鸣音消失、湿啰音消失及平均住院时间治疗组和对照组比较明显缩短,差异均有统计学意义(P均<0.05)。结论布地奈德和利巴韦林联合雾化吸入治疗毛细支气管炎能增强疗效,缓解症状,缩短病程,提高治愈率,安全、有效、简便。
Objective To investigate the clinical effect of budesonide suspension (Pulmicort resp.) Combined with ribavirin inhalation in the treatment of bronchiolitis. Methods A total of 86 children with bronchiolitis were randomly divided into treatment group (43 cases) and control group (43 cases). Budesonide suspension (Pulmicort) at a dose of 0.5 ~ 1mg and ribavirin injection 50mg / time; control group: α-chymotrypsin 5mg / time. Each group of drugs were added to the normal saline 5ml diluted air compression pump inhalation, 2 times / d, 5 ~ 10min / times, once every 5 ~ 7d. The cough, wheezing, shortness of breath, wheezing and wet rales were improved and adverse reactions were observed in all groups. 总? The total effective rate in the treatment group and the control group were statistically significant (χ2 = 4.63, P <0.05) . Wheezing disappeared, relief of shortness of breath, disappearance of wheeze, disappearance of wet rales and average length of stay in treatment group and control group were significantly shorter, the differences were statistically significant (P all <0.05). Conclusion Combining inhalation of budesonide and ribavirin to treat bronchiolitis can enhance the curative effect, relieve the symptoms, shorten the course of disease and improve the cure rate. It is safe, effective and simple.