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目的观察黄体酮注射液联合硝苯地平片治疗输尿管上段结石的临床疗效。方法将94例输尿管上段结石患者随机分为对照组47例与试验组47例。对照组给予盐酸消旋山莨菪碱注射液5~10 mg,qd,肌内注射;试验组在对照组的基础上给予黄体酮注射液20 mg,bid,肌内注射,硝苯地平片10 mg,tid,舌下含服。2组均治疗14 d。比较2组患者的临床疗效、治疗前后血清C-反应蛋白(CRP)、白细胞介素-6(IL-6)水平及药物不良反应发生情况。结果治疗后,试验组和对照组的总有效率分别为95.74%(45/47例)和82.98%(39/47例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的CPR分别为(2.17±0.25),(3.45±0.42)mg·L(-1);IL-6分别为(4.72±0.51),(8.34±0.89)ng·L~(-1),差异均有统计学意义(P<0.05)。试验组主要药物不良反应为口干、视物模糊、皮疹;对照组主要药物不良反应为口干、心跳加速、排尿困难以及皮疹,试验组和对照组的药物不良反应发生率分别为6.38%和10.64%,差异有统计学意义(P>0.05)。结论黄体酮联合硝苯地平治疗输尿管上段结石的临床疗效显著,安全性高。
Objective To observe the clinical efficacy of progesterone injection combined with nifedipine tablet in the treatment of upper ureteral calculi. Methods A total of 94 patients with upper ureteral calculi were randomly divided into control group (n = 47) and experimental group (n = 47). The control group was given racemic anisodamine hydrochloride injection 5 ~ 10 mg, qd, intramuscular injection; the experimental group on the basis of the control group given progesterone injection 20 mg, bid, intramuscular injection of nifedipine tablets 10 mg , tid, sublingual. Both groups were treated for 14 days. The clinical efficacy, serum C-reactive protein (CRP), interleukin-6 (IL-6) levels and adverse drug reactions were compared between the two groups before and after treatment. Results After treatment, the total effective rates of the experimental group and the control group were 95.74% (45/47 cases) and 82.98% (39/47 cases) respectively, the difference was statistically significant (P <0.05). After treatment, the CPR of test group and control group were (2.17 ± 0.25) and (3.45 ± 0.42) mg · L -1, respectively. The levels of IL-6 were (4.72 ± 0.51) and (8.34 ± 0.89) ng · L ~ (-1), the differences were statistically significant (P <0.05). The main adverse drug reactions in the experimental group were dry mouth, blurred vision and rash. The main adverse drug reactions in the control group were dry mouth, accelerated heartbeat, dysuria and rash. The adverse drug reaction rates of the experimental group and the control group were 6.38% and 10.64%, the difference was statistically significant (P> 0.05). Conclusion Progesterone combined with nifedipine in the treatment of upper ureteral calculi clinical significant effect, high safety.