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目的探讨脑室内节细胞胶质瘤(GG)的病理诊断、鉴别诊断及预后。方法收集了2例脑室内GG,并结合国内已报道病例分析临床特点,组织学形态及预后。结果患者临床上主要症状为头痛、呕吐,其次为视力减退及癫。镜下肿瘤细胞形态多样,由肿瘤性胶质细胞(毛细胞性星形细胞瘤或少突胶质细胞瘤样成分)及发育不良的节细胞组成,可见Rosenthal纤维及嗜酸性颗粒小体,伴少许钙化及血管周淋巴细胞袖套形成。结论脑室内GG较为少见,多为WHOⅠ级肿瘤,手术切除后预后较好。因该肿瘤少见,镜下形态多样,易与多种肿瘤混淆,根据其胶质神经元组织学特征并进行相应的免疫组化检测有助于鉴别诊断,准确诊断对治疗及预后具有重要意义。
Objective To investigate the pathological diagnosis, differential diagnosis and prognosis of intracerebral ganglioneuroblastoma (GG). Methods Two cases of intracerebroventricular GGs were collected. Combined with the reported cases in China, clinical features, histological features and prognosis were analyzed. Results The main clinical symptoms of patients with headache, vomiting, followed by vision loss and epilepsy. Microscopically, the morphology of the tumor cells varied from neoplastic glial cells (hairy astrocytoma or oligodendroglioma-like components) and dysplastic ganglion cells, showing Rosenthal fibers and eosinophilic granules, with A little calcification and perivascular lymphocyte sleeve formation. Conclusions Intravenous GG is rarer and most of them are grade I tumors in WHO. The prognosis is good after surgical resection. Because of the rare tumor, microscopic morphology, easily confused with a variety of tumors, according to its glial neuronal histological features and the corresponding immunohistochemical detection is helpful in differential diagnosis, accurate diagnosis of the treatment and prognosis of great significance.