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在异辛酸亚锡催化下,ε-己内酯与官能团化ε-己内酯单体6-(乙酸苄基酯基)-ε-己内酯(BCL)开环共聚合成含有侧乙酸苄基酯基的ε-己内酯/6-(乙酸苄基酯基)-ε-己内酯共聚物(PCL-co-PBCL).然后通过钯/碳催化加氢脱除PCL-co-PBCL的苄基保护基,得到含侧乙羧基官能团的ε-己内酯/6-乙酸基-ε-己内酯共聚物(PCL-co-PCCL).研究了两种聚合物的力学性能、表面亲水性及其在37℃温度下在不同pH值的缓冲溶液中的降解行为.实验结果表明:侧基官能团,尤其是侧乙羧基官能团的引入可明显改善聚己内酯的亲水性和降解性,且降解速度可通过控制聚合物中官能团的含量来进行调节.
Under the catalysis of stannous octoate, ring-opening copolymerization of ε-caprolactone with functionalized ε-caprolactone monomer 6- (benzyl acetate) -ε-caprolactone (BCL) Epsilon-caprolactone / 6- (benzyl acetate) -epsilon caprolactone copolymer (PCL-co-PBCL) was then catalytically hydrogenated over palladium on carbon to remove PCL-co-PBCL Benzyl protected group to get ε-caprolactone / 6-acetoxy-ε-caprolactone copolymer (PCL-co-PCCL) with side-B carboxyl functional groups.The mechanical properties of the two polymers were investigated, Aqueous solution and its degradation behavior under different pH values in buffer solution at 37 ℃ .The experimental results show that the introduction of pendant functional groups, especially the sidecarbinato functional groups can obviously improve the hydrophilicity and degradation of polycaprolactone The rate of degradation can be adjusted by controlling the amount of functional groups in the polymer.