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第10号染色体上缺失的与张力蛋白同源的磷酸脂酶(PTEN)是随p53以后呈现最高突变率抑癌基因表达产物,含403个氨基酸,相对分子质量50×103,基因定位在10q 23.3,是一种存在于胞质中的磷酸脂酶。它在细胞内信号转导通路的调控中起关键作用,不但参与正常细胞生长、发育的调控,而且在
The phosphotransferase (PTEN) which is homologous with the tensin protein deleted on chromosome 10 is the tumor suppressor gene expression product with the highest mutation rate after p53, containing 403 amino acids, the relative molecular mass is 50 × 103, and the gene is located at 10q 23.3 , Is a phospholipase present in the cytoplasm. It plays a key role in the regulation of intracellular signaling pathways, not only in the regulation of normal cell growth and development, but also in