鲍曼不动杆菌是一种常见的院内感染菌,由于碳青霉烯类在临床上的经常使用,细菌对碳青霉烯类耐药率逐年增高。其耐药机制涉及因素较多,其中主要是产生碳青霉烯酶、膜孔道蛋白缺失、药物主动外排和青霉素结合蛋白改变等。耐药性的产生通常是由其中一种或几种机制共同作用导致。在耐药性的传播方面,质粒和整合子可能起到一定作用,但可能还是以克隆株的水平传播为主。 Acinetobacter baumannii is a common nosocomial infection bacteria, due to the frequent use of carbapenems clinically, the rate of carbapenem resistance increased year by year. Its resistance mechanism involves many factors, including the main carbapenemases, membrane pore protein deletion, active drug efflux and penicillin-binding protein changes. Drug resistance is usually caused by the action of one or more of these mechanisms. Plasmids and integrons may play a role in the spread of drug resistance, but may still predominate at the level of clonal strains.