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目的：讨论研究应用依托考昔与美洛昔康用于治疗急性痛风的临床疗效与意义，并总结药物对患者的安全性。方法：选取我院风湿科科急性痛风患者100例。随机分组为A、B两组。A组患者使用依托考昔进行治疗；B组患者应用美洛昔康对其进行治疗。比较两组患者不同治疗后总有效率、不良反应等指标。结果：不同药物治疗后总有效率比较 B组患者应用火针点刺放血疗法联合中医护理进行治疗总有效率为100%显著高于使用常规治疗方法患者总有效率90%（P＜0.05）。治疗后不良反应发生人数比较显示A组患者使用依托考昔治疗后各类不良反应发生人数均显著少于使用美洛昔康患者（P＜0.05）。结论：临床通应用依托考昔与美洛昔康治疗急性痛风均有显著疗效。依托考昔能够在短时间内缓解患者疼痛症状且吸收迅速。治疗后不良反应较少，安全系数高，患者依从性及耐受性较好，能够显著提高疾病治疗效率并加快患者速度，对促进其预后并改善生活质量具有重要意义。“,”Objective Discussion on Application of etoricoxib and meloxicam for clinical curative effect and the significance of the treatment of acute gouty arthritis, and concludes on the safety ofmedication.Methods A total of 100 patients in our hospital with acute gout rheumatism koko. Were randomly divided into A, B two groups. Patients in group A with etoricoxib treatment; group B patients of meloxicam treatmenton it. Compared two groups of patients with different treatment after the total efficiency, adverse reactions and other indicators.Results Different drug treatment after the total efficiency compared with the B group of patients with fire needle pricking blood therapy combined with traditional Chinese medicine nursing treatment the total effective rate was 100%, significantly higher than that ofpatients with conventional treatment the total effective rate was 90% (P < 0.05). After treatment, number of adverse reactions compared A group with etoricoxib treatment of adverse reactions after the occurrence of various numbers were significantly less than the use of meloxicam patients (P < 0.05).Conclusion Clinical application of etoricoxib and meloxicam in treatment of acute gout has notable curative effect. Etoricoxib in a short time can relieve pain and rapid absorption. Adverse reaction after treatment is less, high safety coefficient, the compliance of patients and well tolerated, can significantly improve the treatment efficiency and accelerate the speed of disease patients, topromote their prognosis and improve the quality of life has important significance.