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目的了解肺结核人群中的戊型肝炎(戊肝)流行特征,为更有效地开展肺结核和戊肝防治工作提供科学依据。方法采集2015年10月至2016年9月采集湖北省安陆市173人肺结核患者的血清,进行肝功能、抗-HEV IgG和抗-HEV IgM检测,对抗-HEV IgM阳性样本进行HEV RNA检测,同时收集其人口学资料和其他疾病感染史。结果共调查173例肺结核人群,肺结核人群抗-HEV IgM阳性率为0.58%(1/173),肺结核人群抗-HEV IgG阳性率为38.73%(67/173),HEV RNA未检出。肺结核患者中抗-HEV IgG阳性率与年龄呈线性关系,随年龄增加而增加。肺结核患者有肝功能异常史的戊肝既往感染率较高。肺结核患者中抗-HEV IgG阳性率在性别、肺结核病程长短、区域、职业上分布差异均无统计学意义(P>0.05)。结论活动期的肺结核人群HEV感染不容忽视,积极开展两病双向筛查的同时需采取针对性的预防和治疗措施。
Objective To understand the epidemiological characteristics of hepatitis E (hepatitis E) in patients with pulmonary tuberculosis and provide a scientific basis for the prevention and control of tuberculosis and hepatitis E more effectively. Methods Sera from 173 patients with pulmonary tuberculosis in Anlu City of Hubei Province from October 2015 to September 2016 were collected to detect liver function, anti-HEV IgG and anti-HEV IgM, HEV RNA was detected in anti-HEV IgM positive samples, At the same time to collect their demographic data and other history of disease infection. Results A total of 173 cases of pulmonary tuberculosis were investigated. The positive rate of anti-HEV IgM in tuberculosis was 0.58% (1/173). The positive rate of anti-HEV IgG in tuberculosis was 38.73% (67/173). HEV RNA was not detected. The positive rate of anti-HEV IgG in patients with pulmonary tuberculosis was linear with age and increased with age. Patients with tuberculosis have a history of liver dysfunction, past infection of hepatitis E higher. The positive rate of anti-HEV IgG in tuberculosis patients was not statistically significant (P> 0.05) in gender, length of tuberculosis course, regional and occupational distribution. Conclusions The active stage of pulmonary tuberculosis can not be ignored HEV infection, and actively carry out bi-directional screening of both diseases need to take targeted preventive and therapeutic measures.