【摘 要】
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Mitochondrial calcium uniporter (MCU) is a highly selective Ca2+ channel protein of the mitochondria inner membrane [1],which allows divalent cations (Ca2+ ≈ S
【机 构】
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Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Provin
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Mitochondrial calcium uniporter (MCU) is a highly selective Ca2+ channel protein of the mitochondria inner membrane [1],which allows divalent cations (Ca2+ ≈ Sr2+(>>) Mn2+ ≈ Ba2+) to permeate [2].The MCU is a 40-kDa protein that contains a proteolytically cleaved mitochondrial import sequence,two coiled-coil domains,two transmembrane domains,and a short motif of amino acids between the two transmembrane domains critical for Ca2+ transport [3].MCU is widely expressed in the mitochondrial inner membrane of various cells [4].In addition,MCU is also a highly conserved protein among different species (Fig.1A),suggesting that MCU may play an essential role in the process of physiology and pathology.
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