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目的比较地屈孕酮片和黄体酮栓在体外受精中对胚胎植入率、妊娠率和自然流产率的影响,了解地屈孕酮片在体外受精中黄体支持的作用效果。方法以2007年1~6月接受体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)的病人554例(孕酮栓组),使用黄体酮栓支持黄体;2008年1~6月接受IVF/ICSI-ET病人816例(地屈孕酮组),用地屈孕酮片支持黄体,比较两组胚胎种植率、临床妊娠率、流产率。结果两组患者的胚胎种植率、妊娠率、自然流产率比较差异无统计学意义(P>0.05)。结论地屈孕酮和黄体酮栓在辅助生育技术过程中均有效用于黄体支持,两者的疗效相当。
Objective To compare the effect of dydrogesterone tablets and progesterone suppositories on embryo implantation rate, pregnancy rate and spontaneous abortion rate in in vitro fertilization and to understand the effect of dydrogesterone tablets on luteal support in in vitro fertilization. Methods 554 patients (progesterone-suppository group) received in vitro fertilization / intracytoplasmic sperm injection-embryo transfer (IVF / ICSI-ET) from January 2007 to June 2007 with progesterone suppository to support luteal phase. From June to June, 816 patients (dydrogesterone group) received IVF / ICSI-ET, and received progesterone tablets to support corpus luteum. Embryo implantation rate, clinical pregnancy rate and abortion rate were compared between the two groups. Results There was no significant difference in embryo implantation rate, pregnancy rate and spontaneous abortion rate between the two groups (P> 0.05). CONCLUSION: Dydrogesterone and progesterone suppositories are effective for luteal support in both assisted reproductive technologies, and their efficacy is comparable.