喹诺酮类抗菌药物一直是国内外研究的热点 ,尤其近年来 ,取得飞跃的发展。60年代初第一代喹诺酮类药物如萘啶酸、恶喹酸、吡咯酸等相继问世。由于其对中枢神经系统有毒副作用 ,现已少用。 70年代出现的第二代如吡啉酸、氟喹酸、吡哌酸等抗菌活性和抗菌谱较第一代强和广 ,但抗菌 Quinolone antibacterials have always been the hotspot of research at home and abroad, especially in recent years, have made leaps and bounds. The first generation of quinolones in the early 1960s such as nalidixic acid, oxolinic acid, pyrrole acid and so on have come out. Because of its toxic side effects of the central nervous system, is now less used. The second generation appeared in the 70’s such as the acid, the quinolinic acid, piperine and other antibacterial activity and antimicrobial spectrum stronger and broader than the first generation, but the antibacterial