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目的探讨白细胞介素4(IL4)(C589T)基因多态性与胆石病发病例因素的相关性。方法采用聚合酶链式反应限制性片段长度多态性分析(PCRRFLP)技术对中国南京地区81例胆囊结石患者和41例胆管结石患者进行IL4(C589T)基因型分析。结果胆囊结石组与胆管结石组患者IL4(C589T)基因型频率和等位基因频率有显著性差异(CC分别为11.1%和48.8%、CT分别为34.6%和36.6%、TT分别为54.3%和14.6%、C分别为28.4%和67.1%、T分别为71.6%和32.9%)。结论IL4(C589T)基因多态性与胆管结石的形成存在相关性,与胆囊结石不存在相关性。
Objective To investigate the relationship between interleukin-4 (IL-4) (C589T) gene polymorphism and the incidence of gallstone disease. Methods The genotypes of IL4 (C589T) in 81 patients with gallstones and 41 patients with bile duct stones in Nanjing, China were analyzed by polymerase chain reaction restriction fragment length polymorphism (PCRRFLP). Results There was a significant difference in genotype frequency and allele frequency of IL4 (C589T) between gallstone group and bile duct stone group (CC was 11.1% and 48.8%, CT was 34.6% and 36.6% respectively, TT was 54.3% and 14.6%, C respectively 28.4% and 67.1%, T respectively 71.6% and 32.9%). Conclusion The polymorphism of IL4 (C589T) gene is associated with the formation of bile duct stones, which is not related to gallstone.