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大鼠肠系膜微血管缺血再灌后内皮细胞出现明显改变，缺血再灌后３０ｍｉｎ～１ｈ细静脉、集合毛细血管内除有白细胞、血小板的粘附以及红细胞聚集、血管内皮水肿外，还发现血管内皮细胞的胞浆形成圆丘形的空泡。空泡从血管内壁内壁突入管腔，空泡直径１０～３０μｍ，多发生在直径２０～７０μｍ的细动脉，静脉内也可出现，但不如动脉多。在同一根血管内可同时出现几个空泡，大的空泡几乎堵塞血管腔。严重者几个空泡出现在同一管腔的周围，造成管腔的堵塞，使血细胞不能顺利通过。结果表明血管内皮大空泡的形成将阻碍血液的流动，加重微循环的障碍和血管周围组织细胞的损伤。
After mesenteric microvascular ischemia-reperfusion in rat, the endothelial cells obviously changed. Within 30min ~ 1h after ischemia / reperfusion, there were leucocyte and platelet adhesion, erythrocyte aggregation and vascular endothelial edema in the collecting capillary, vascular The cytoplasm of endothelial cells form a dome-shaped vacuole. Cavitation into the lumen from the inner wall of the vascular wall, vacuolar diameter of 10 ~ 30μm, occurred in the diameter of 20 ~ 70μm fine arteries, can also occur within the vein, but not as many arteries. In the same vein can be several vacuoles at the same time, a large vacuole almost plug the blood vessel. Severe cases of several vacuoles appear in the same lumen around, resulting in lumen congestion, so that blood cells can not be successfully passed. The results show that the formation of large vacuoles in the vascular endothelium will hinder the flow of blood, aggravating microcirculation disorders and perivascular tissue injury.