颅脑损伤是高原地区常见的神经外科急症,由于受高原严寒低氧、低气压等恶劣环境影响,患者病情危重,病程进展快,以致高原颅脑损伤致残率及病死率均明显高于平原地区。已有研究表明,中性粒细胞弹性蛋白酶(NE)在颅脑损伤后表达水平增高,且与损伤程度成正比,并加重颅脑损伤。本文旨 Traumatic brain injury is a common neurosurgical emergency in the plateau. Due to the severe hypoxia and hypobaric hypoxia in the plateau, the patient’s condition is critical and the course of the disease progresses rapidly. As a result, the morbidity and mortality of the traumatic brain injury in the plateau are significantly higher than those in the plain area. Studies have shown that neutrophil elastase (NE) expression increased after craniocerebral injury, and is proportional to the degree of injury, and aggravate traumatic brain injury. The purpose of this article