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目的:明确血清γ-谷氨酰转移酶(GGT)水平能否独立预测2型糖尿病成人冠状动脉(冠脉)钙化进展。方法:326例无心血管疾病症状的2型糖尿病成人患者纳入研究,均接受冠脉成像评估,测量GGT水平,在基线以及随访末使用320CT测量CAC积分。结果:172例(52.8%)患者具有不同程度的冠脉钙化;冠脉钙化进展者GGT水平显著高于非进展者[(39.0±15.6)U/L∶(27.0±10.8)U/L,P<0.001]。单变量分析结果显示,GGT水平能预测冠脉钙化进展;多变量分析结果显示,调整年龄、性别及其他危险因素后,GGT水平仍与冠脉钙化进展具有显著相关性(OR=1.082,95%CI:1.051~1.114,P<0.01)。多变量Cox比例风险模型分型结果显示,年龄和LDL是近期心血管事件的独立预测因子。结论:在没有心血管病症状的2型糖尿病患者中,GGT不仅与基线冠脉钙化具有正相关性,且是冠脉钙化进展的独立预测因子。
Objective: To determine whether the level of serum G-glutamyl transferase (GGT) can independently predict the progression of coronary (coronary) calcification in type 2 diabetic adults. METHODS: A total of 326 adults with type 2 diabetes who did not have symptoms of cardiovascular disease were included in the study and were evaluated for coronary angiography. GGT levels were measured and 320CT was used to measure CAC scores at baseline and at the end of follow-up. Results: 172 patients (52.8%) had different degrees of coronary artery calcification. The level of GGT in patients with progression of coronary artery was significantly higher than that in non-patients [(39.0 ± 15.6) U / L: (27.0 ± 10.8) U / L, P <0.001]. Univariate analysis showed that the level of GGT could predict the progress of coronary artery calcification. Multivariate analysis showed that there was a significant correlation between the level of GGT and the progression of coronary artery calcification (OR = 1.082, 95% CI: 1.051 ~ 1.114, P <0.01). Multivariate Cox proportional hazards model typing results showed that age and LDL were independent predictors of recent cardiovascular events. CONCLUSIONS: In patients with type 2 diabetes who do not have symptoms of cardiovascular disease, GGT is not only positively correlated with baseline coronary artery calcification but is also an independent predictor of progression of coronary calcification.