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目的 :观察丝裂霉素 C(MMC)和卡介苗 (BCG)化学免疫预防膀胱癌术后复发的疗效。方法 :对 86例浅表性膀胱癌患者术后应用 MMC 2 0 mg和 BCG 6 0 m g,每周 1次进行交替膀胱灌注 ,共灌注 12次 ,以后每间隔 3个月灌注 1次 ,持续 2年。结果 :随访 2 .4~ 8年 ,平均 4.8年 ,肿瘤复发率为 8.1%。结论 :MMC和 BCG交替膀胱灌注可减少膀胱癌术后复发率。
Objective: To observe the curative effect of chemical immunization of mitomycin C (MMC) and BCG against postoperative recurrence of bladder cancer. Methods: Eighty-six patients with superficial bladder cancer were treated with MMC 20 mg and BCG 60 mg after operation. The bladder was infused alternately once a week for 12 times. After that, perfusion was performed once every 3 months for 2 year. Results: The follow-up ranged from 2.4 to 8 years, with an average of 4.8 years. The tumor recurrence rate was 8.1%. CONCLUSION: Alternate intravesical instillation of MMC and BCG can reduce the postoperative recurrence rate of bladder cancer.