以考马斯亮兰G-250为模型药物,分别以Ca2+、Fe3+、Zn2+、Ba2+为交联剂,采用滴制法制备果胶凝胶微丸,考察不同离子交联制备的果胶凝胶微丸溶胀度和释药行为的差异。结果表明,不同离子交联制备的果胶凝胶微丸的溶胀行为和释药行为有明显差异。果胶凝胶微丸可通过采用不同离子交联制备获得不同缓释效果,是一种非常有潜力的药物载体和细胞微囊化载体。 Using Coomassie brilliant blue G-250 as model drug, Ca2 +, Fe3 +, Zn2 + and Ba2 + were used as cross-linking agent to prepare pectin gel pellets by dropping method. The effects of different ion crosslinked pectin gel pellets Differences in swelling and drug release behavior. The results showed that the swelling behavior and release behavior of pectin gelled pellets prepared by different ionic cross-linking were significantly different. Pectin gel pellets can be obtained by different ion-crosslinking preparation to obtain different sustained-release effect, which is a very promising drug carrier and microcapsule carrier.