利用药物加速矫治牙移动以缩短疗程,已引起正畸界的兴趣。笔者收集近年来国内外有关文献,在病理学基础上分类常用药物,并阐述其相应机理。一、药物矫治的组织病理学基础:外力使矫治牙移动而造成对牙周组织的轻微创伤,可导致一定程度的炎症反应。但这种损伤及炎症是可修复的。很多学者认为炎症是导致矫治牙移动过程中牙周吸收及改建的重要因素。药物加速矫治牙移动的实质就是利用药物的促炎因素,来诱导、促发牙周组织中可修复的炎症,加速牙周改建。矫治牙移动中的炎症反应有三个重要环节:炎症 The use of drugs to speed up the correction of tooth movement to shorten the course of treatment has caused the orthodontic community's interest. I collected in recent years, relevant literature at home and abroad, based on the pathological classification of commonly used drugs, and elaborated on the corresponding mechanism. First, the basis of the histopathology of drug treatment: external force to orthodontic tooth movement caused by minor trauma to the periodontal tissue can lead to a degree of inflammatory response. But this damage and inflammation are repairable. Many scholars believe that inflammation is an important factor that leads to periodontal absorption and remodeling during tooth movement. Drugs to accelerate the treatment of tooth movement is the essence of the use of drug proinflammatory factors to induce and promote repair of the periodontal tissue inflammation and accelerate periodontal reconstruction. There are three important links in correcting the inflammatory response during tooth movement: inflammation