本文提出,在密闭系统中,当水的摩尔数低于(或接近于)药物的摩尔数时,发生水解反应,每分解1分子药物将消耗(而不是再产生)1分子的水,当然,也有消耗大于1分子水的情况,如安定。阿司匹林分解是在限量湿气存在下明显地按1:1的方式进行的,即阿司匹林水解形成醋酸和水杨酸。 This paper suggests that in a closed system, when the number of moles of water is less than (or near) the number of moles of drug, a hydrolysis reaction occurs that consumes (rather than regenerates) one molecule of water per molecule of decomposition and, of course, There are also consumption of more than 1 molecule of water, such as stability. Aspirin Decomposition was apparently performed in a 1: 1 ratio in the presence of a limited amount of moisture, that is, aspirin hydrolyzed to form acetic acid and salicylic acid.